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Not all sufferers with CLL call for therapy. Even with all modern improvements, the iwCLL however suggests watchful observation for sufferers with asymptomatic ailment.86 This suggestion is based on a minimum of two randomized trials comparing observation to possibly chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR).
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優越的地位の濫用規制について① '- 優越的地位の濫用は︑契約の不完備性に関する問題であり︑契約の不完備性が情報の不完全性によると考えれば︑
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This methylation profile is previously obtained within the MBL stage3 and stays rather secure eventually. Nonetheless, some CLL have intratumor variability in particular locations, which may change the expression of many genes and aid tumor evolution.71 Of Notice, this variability is greater in U-CLL than in M-CLL which is linked to increasing amount of subclones.7,seventy one
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